发明名称 |
Osteogenic device and a method for preparing the device |
摘要 |
The present invention is related to an osteogenic device and its preparation. Said device comprises a bone morphogenetic protein (BMP), preferably a modified BMP complex obtainable by a modification of the conventional guanidum hydrochloride extraction method and collagens, preferably collagen I or collagen IV, impregnated in and/or adsorbed on a bioceramic carrier, preferably a shapable body (block) originating from a coral skeleton. The method of isolating said modified BMP complex which lacks an immunogenic component and consists essentially of a 100-700 kD and a 15-25 kD protein with osteoinductive properties and preferably of the 15-25 kD protein which has improved storage properties as well as its use in the osteogenic device with improved osteoinductive properties is also disclosed.
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申请公布号 |
US7186811(B2) |
申请公布日期 |
2007.03.06 |
申请号 |
US20040759244 |
申请日期 |
2004.01.20 |
申请人 |
BIOACTIVE BONE SUBSTITUTES OY, AB |
发明人 |
LINDHOLM SAM T.;MARTTINEN AULIS |
分类号 |
C07K1/36;A61F2/00;A61L;A61L27/22;A61L27/24;A61L27/36;A61L27/54;C07K1/16;C07K1/34;C07K14/51 |
主分类号 |
C07K1/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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