Fusion protein with specific bond to human interleukin-4, nucleic acid molecule, monoclonal antibodies, pharmaceutical composition and their use

摘要

A fusion protein having binding specificity for human interleukin-4 (IL-4) which comprises complementarity determining regions (CDRs) derived from a non-human neutralizing monoclonal antibody with a dissociation constant equal to or less than 2.10exp(-10) M, and a first fusion partner. A nucleic acid molecule encoding a fusion protein, monoclonal antibodies, pharmaceutical compositions comprising its and their use.