METHODS OF PREPARING POLYMERS HAVING TERMINAL AMINE GROUPS

摘要

The present invention is directed to methods of preparing linear polymers such
as polyalkylene oxides containing a terminal amine in high purity. One
preferred method includes reacting a polyalkylene oxide such as polyethylene
glycol containing a terminal azide with a phosphine-based reducing agent such
as triphenylphosphine or an alkali metal borohydride reducing agent such as
sodium borohydride in a solvent to reflux. The resultant polymer-amines are of
sufficient purity so that expensive and time consuming purification steps
required for pharmaceutical grade polymers are avoided.