| 发明名称 |
BIS-ARYL UREA COMPOUNDS FOR THE TREATMENT OF PROTEIN KINASE-MEDIATED DISEAES |
| 摘要 |
<p>The present invention relates to compounds of Formulas (I) and (II), wherein A<SUP>1</SUP>, A<SUP>2</SUP>, B<SUP>1</SUP>, B<SUP>2</SUP>, Q, X<SUP>1</SUP>, X<SUP>2</SUP>, Y and R<SUP>3</SUP> are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.</p> |
| 申请公布号 |
WO2007024754(A1) |
申请公布日期 |
2007.03.01 |
| 申请号 |
WO2006US32509 |
申请日期 |
2006.08.18 |
| 申请人 |
AMGEN INC.;GEUNS-MEYER, STEPHANIE D.;CHAFFEE, STUART C.;JOHNSON, REBECCA E.;KIM, JOSEPH L.;NUNES, JOSEPH J.;PATEL, VINOD F |
发明人 |
GEUNS-MEYER, STEPHANIE D.;CHAFFEE, STUART C.;JOHNSON, REBECCA E.;KIM, JOSEPH L.;NUNES, JOSEPH J.;PATEL, VINOD F |
| 分类号 |
C07D239/48;A61K31/435;A61K31/505;A61K31/53;A61P35/00;C07D213/81;C07D239/42;C07D239/74;C07D251/18;C07D403/12;C07D417/12;C07D487/04 |
主分类号 |
C07D239/48 |
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