Novel BRAF<SUP>V600E</SUP> mutant peptides or a pharmaceutically acceptable salt thereof, that induce MHC Class I-dependent cytotoxic T cell responses in mammals are useful in prophylactic, diagnostic and therapeutic treatments for melanoma. Such compounds are also useful in drug development for non-peptide mimics of the compounds described herein and in the development of therapeutic or diagnostic antibodies.
申请公布号
WO2007002811(A3)
申请公布日期
2007.03.01
申请号
WO2006US25324
申请日期
2006.06.28
申请人
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY;HERLYN, DOROTHEE;SOMASUNDARAM, RAJASEKARAN;OTVOS, LAZLO