PREVENTION OF CHRONIC REJECTION IN SOLID ORGAN TRANSPLANTATION

摘要

The present invention relates to the use of recombinant adenoassociated virus (rAAV) vectors to transduce cells of a solid organ to be transplanted with a nucleic acid sequence encoding an immunomodulatory polypeptide, e.g. IL-IO, the expression of which reduces the likelihood of rejection of the transplanted organ by the host immune system. Methods of improving the efficiency of solid organ transplantation by administering rAAV vectors encoding IL-IO to an isolated solid organ prior to transplantation of that organ into a subject are also described. The solid organ to be transduced may be the heart, kidney, liver, pancreatic islet, lung, or intestine.