CRYSTAL STRUCTURES AND MODELS FOR Fc RECEPTORS AND USES THEREOF IN THE DESIGN OR IDENTIFICATION OF Fc RECEPTOR MODULATOR COMPOUNDS

摘要

The invention relates to the determination of the three-dimensional structures of Fc receptor proteins, particularly wild-type FcgammaRIIa, by X-ray crystallography and the use of the structure in identifying and modifying agents for modulating the biological activity of Fc receptors. Also disclosed is a novel dimeric structure for FcgammaRIIa and novel target sites for agents for modulating the biological activity of Fc receptor proteins.