F11 RECEPTOR (F11R) ANTAGONISTS AS THERAPEUTIC AGENTS

摘要

The present invention provides a cell adhesion molecule (CAM), designated FI l receptor (Fl IR), which is a member of the immunoglobulin super family localized on the surface of human platelets, and determined to effect platelet aggregation, secretion, platelet spreading and cellular adhesion. Cloned FI lR cDNA and full length FI lR cDNA and amino acid sequences are provided. Fl lR-antagonists and methods for the prevention and treatment of thrombosis, atherosclerosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided.