Polymer precursors of radiolabeled compounds, and methods of making and using the same

摘要

A polymer precursor compound represented by 1:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒPoly--L---R----Y
wherein:
Poly represents a polymer;
L is selected from:
R represents polycyclic aryl or heteroaryl;
Y represents hydrogen, alkyl, alkoxyl, carbonyl, formyl, amido, amino, alkylamino, dialkylamino, carboxamido, acylamino, (heterocyclcyl)acylamino, alkylcarboxyamido, C(O)-R 4 , or C(O)NH-R 4 ;
R 3 represents independently for each occurrence alkyl, alkenyl or alkynyl;
R 4 represents hydrogen, alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, peptide, protein, amino acid, antibody, nucleotide, nucleoside, or -(CH 2 ) m -R 80 ;
R 80 represents independently for each occurrence aryl, cycloalkyl, cycloalkenyl, heterocyclyl, or polycyclyl; and
m is an integer in the range 0 to 8 inclusive.
The polymer precursor is used for preparing radiolabeled compounds.