COMPOSITIONS AND METHODS FOR TREATING MALARIA

摘要

Polyene macrolide compounds, analogues thereof and compositions containing polyene macrolides or analogues are described for use in treating malaria infections in humans and animals. Examples of polyene macrolide compounds are amphotericin B, nystatin A, natamycin (pimaricin), filipin, rimocidin, candidin and vacidin, and in particular, formulations similar to those described for amphotericin B, such as amphotericin B deoxycholate, amphotericin B colloidal dispersion, amphotericin B lipid complex and liposomal amphotericin B. The polyene macrolide may be produced by a microorganism, by chemically modifying a polyene macrolide or via de novo synthesis. The analogue may be chemically modified to improve solubility, bio-availability and/or bio-activity or limit toxicity. The polyene macrolide or analogue may be administered together with one or more other antimalarial compounds, such as chloroquine, quinine, quinidine, mefloquine, halofantrine, sulfonamides, tetracyclines, atovaquone, artemisinin compounds, rimaquine, proguanil or pyrimethamine, so as to increase the efficacy of the other antimalarial compound.