发明名称 |
REVASCULARIZATION OF ISCHEMIC RETINAL TISSUE AND SCREENING METHOD THEREFOR |
摘要 |
The present invention provides a treatment method for promoting beneficial physiological revascularization of ischemic retinal tissue. The method comprises administering to a mammal suffering from a retinal vascular ischemia a therapeutically effective amount of an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS), thereby simultaneously inhibiting pathological neovascularization while promoting beneficial physiological revascularization of damaged areas of the retina. In a preferred embodiment, the angiostatic fragment of TrpRS is T2-TrpRS or T2-TrpRS-GD. Preferably, the mammal is a human patient suffering from retinal ischemia. A screening method for identifying and evaluating therapeutic agents for treating retinal neovascular diseases is also disclosed. |
申请公布号 |
WO2006091729(A3) |
申请公布日期 |
2007.03.01 |
申请号 |
WO2006US06402 |
申请日期 |
2006.02.24 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;FRIEDLANDER, MARTIN;BANIN, EYAL;AGUILAR, EDITH |
发明人 |
FRIEDLANDER, MARTIN;BANIN, EYAL;AGUILAR, EDITH |
分类号 |
A01N37/18;A61K38/00;G01N33/567 |
主分类号 |
A01N37/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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