SECRETORY ANTIGEN 1 PROTEIN OF BABESIA GIBSONI, DNA ENCODING THE SAME AND USE THEREOF

摘要

[PROBLEMS] It is intended to provide a major antigen gene and a major antigen protein of B. gibsoni protozoa. Further, it is intended to provide a diagnostic antigen, a vaccine for prevention and the like for canine B. gibsoni infection using the gene. [MEANS FOR SOLVING PROBLEMS] A DNA encoding a secretory antigen 1 (BgSA1) protein of B gibsoni protozoa; an expression product of a BgSA1 gene (recombinant BgSA1 protein); a synthetic peptide based on a BgSA1 gene sequence; a therapeutic preparation using an antiserum or an antibody against the recombinant BgSA1 protein and the BgSA1 synthetic peptide; a diagnostic preparation using the recombinant BgSA1 protein or the BgSA1 synthetic peptide as an antigen; a DNA diagnosis targeting the BgSA1 gene; a vaccine preparation for prevention using the recombinant BgSA1 protein or the BgSA1 synthetic peptide; a recombinant virus vaccine in which the BgSA1 gene has been integrated; a plasmid vaccine in which the BgSA1 gene has been integrated (DNA vaccine).