发明名称 NOVEL ARYLOXYPHENYLPROPANAMINES
摘要 The present invention relates to a non-radioactive, heavy-atom isotopologue of Compound 1 containing one or more deuterium in place of a hydrogen covalently bound to carbon. The Compound 1 isotopologues of the invention are inhibitors of norepinephrine uptake and possess unique biopharmaceutical and pharmacokinetic properties compared to the corresponding non-isotope containing compounds. They may also be used to accurately determine the concentration of Compound 1 in biological fluids. The invention further provides compositions comprising these heavy-atom Compound 1 isotopologue and methods of treating diseases and conditions linked to reduced neurotransmission of norepinephrine.
申请公布号 WO2007005643(A3) 申请公布日期 2007.03.01
申请号 WO2006US25651 申请日期 2006.06.30
申请人 CONCERT PHARMACEUTICALS INC.;TUNG, ROGER 发明人 TUNG, ROGER
分类号 A01N43/40;A61K31/44 主分类号 A01N43/40
代理机构 代理人
主权项
地址