Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist

摘要

According to one aspect of the invention, there is provided a pharmaceutical formulation for administration by inhalation comprising a compound of formula (I),
wherein
R 1 represents C 1-6 alkyl or C 1-6 haloalkyl;
R 2 represents -C(=O)-aryl or -C(=O)-heteroaryl;
R 3 represents hydrogen, methyl (which may be in either the ± or ² configuration) or methylene;
R 4 and R 5 are the same or different and each represents hydrogen or halogen; and represents a single or a double bond;
and salts and solvates thereof together with a long-acting ² 2 -adrenoreceptor agonist which formulation has a therapeutically useful effect in the treatment of inflammatory disorders of the respiratory tract over a period of 24 hours or more.