Process for the homogeneous hydrogenation of ketones using ruthenium catalytic systems.

摘要

To have an industrial applicable process for the reduction of C 1 -C 6 alkyl ketones (including prochiral) or their deuterated derivatives in huge quantities for obtaining their respective alcohols. To provide a new process for the preparation of secondary alcohols substituted with C 1 -C 6 alkyl chain or their deuterated derivatives. The process comprises the hydrogenation of ketones (including prochiral) using Rutenium achiral or chiral catalytic systems to render racemic or nonracemic chiral alcohols or deuterated racemic or nonracemic chiral alcohols under low pressure and room temperature.