摘要 |
A vitamin C derivative is provided to show excellent stability and skin permeation by introducing a phosphoric acid derivative and a collagen generating peptide thereinto. The vitamin C derivative is represented by the formula(1), where each R1 and R2 is independently OH or a group represented by the structural formula(1-1)(where X is -OC(O)(CH2)mC(O)-, a group represented by the structural formula(1-2) is a peptide where at least one amino acid residue selected from the group consisting of glycine, lysine, histidine, serine, proline, hydroxyproline, threonine, glutamic acid, methionine, glutamine and arginine is amide-coupled, R is a side branch of the amino acid residue, n is an integer from 3 to 10, and m is an integer from 2 to 5), and W is a group represented by the structural formula(1-3) or glucose(where R3 is -N(CH3)2, -N(CH2CH3)2, -NHCH2CH2CH3, -NHCH2C6H5 or -OH). The skin whitening composition comprises at least one of the vitamin C derivative or a pharmaceutically acceptable salt thereof. |
申请人 |
PEPTRON CO., LTD. |
发明人 |
PARK, JONG IL;KIM, HEUNG JAE;KIM, DONG WON;LIM, CHAE JIN;KANG, JONG PHIL;PARK, KYEONG YONG;YOON, SEOK JEONG;KWON, SEON DEOK;CHOI, HO IL |