| 摘要 |
The invention relates to a process for the preparation of the (E) N-methyl-N-1-(naphthylmethyl)-6,6-dimethylhept-2-ene-4-ynyl-1-amine for formula (I), listed in the description, and the acid additionsalts thereof wherein the chloro-compound of formula (IIIb) - containing the E and Z isomers of ratio 3.3-3.4.1 and obtained by the reaction of the secondary alcohol for formula (IV) with hydrochloric acid - is reacted with the secondary amine of formula (II) of the description in an aliphatic ketone-type solvent in the presence of a base and optionally iodide salt catalysts, then the obtained compound of formula (I) in the base form and in ratio of isomers 3.3 - 3.4 : 1 is converted with hydrochloric acid directly to the hydrochloride salt, the precipitated hydrochloride of the E-isomer is separated, optionally the base is liberated and converted - by a known method - to pharmaceutically acceptable acid addition salt. The product obtained by the process related to the invention is the active agent of a known antifungal drug.
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