发明名称 |
MODIFIED TNFalpha MOLECULES, DNA ENCODING SUCH MODIFIED TNFalpha MOLECULES AND VACCINES COMPRISING SUCH MODIFIED TNFalpha MOLECULES AND DNA |
摘要 |
<p>A modified human TNFalpha molecule is capable of raising neutralizing antibodies towards unmodified human TNFalpha following administration of the modified TNFalpha to a human host, wherein one or more peptide fragments of the human TNFalpha molecule has been substituted by one or more peptides containing immunodominant T cell epitopes or a truncated form of the molecule containing the immunodominant epitope and one or both flanking regions of the human TNFalpha-molecule containing at least one TNFalpha B cell epitope, wherein the substitution introduces a substantial change in the amino acid sequence of any one of the strands of the front beta-sheet, in any one of the connecting loops, or in any one of the B', I, or D strands of the back beta-sheet.</p> |
申请公布号 |
SI0975668(T1) |
申请公布日期 |
2007.02.28 |
申请号 |
SI19980030845T |
申请日期 |
1998.04.15 |
申请人 |
PHARMEXA A/S |
发明人 |
JENSEN MARTIN ROLAND;MOURITSEN SOREN;ELSNER HENRIK;DALUM IBEN |
分类号 |
G01N33/53;A61K;A61K31/505;A61K38/00;A61K38/19;A61K38/22;A61K39/00;A61P1/04;A61P3/10;A61P11/06;A61P17/06;A61P19/02;A61P19/10;A61P29/00;A61P35/00;C07K9/00;C07K14/33;C07K14/525;C07K16/24;C07K19/00;C12N;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/11;C12N15/28;C12N15/63;C12P21/02 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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