摘要 |
<p>This application relates to antibodies, e.g ., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders ( e.g., asthma); atopic disorders ( e.g ., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin ( e.g., atopic dermatitis), and gastrointestinal organs ( e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.</p> |
申请人 |
WYETH |
发明人 |
LIN, LAURA, LONG;PARRIS, KEVIN, D.;TAM, AMY, SZE, PUI;TAN, XIANG-YANG;SHANE, TANIA;DUMAS, JOHN;WILHELM, JAMES, M.;STAHL, MARK;MOSYAK, LIDIA;HU, ZHIXIANG |