发明名称 |
Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
摘要 |
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
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申请公布号 |
US7183408(B2) |
申请公布日期 |
2007.02.27 |
申请号 |
US20050109396 |
申请日期 |
2005.04.19 |
申请人 |
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发明人 |
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分类号 |
C07D413/06;A61K31/4025;C07B61/00;C07D207/34;C07D295/18;C07D295/185;C07D401/06;C07D405/06;C07D413/04 |
主分类号 |
C07D413/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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