ADHESIVENESS ENHANCED ANIMAL CELLS INTRODUCED WITH TISSUE TRANSGLUTAMINASE AND PROTEIN TRANSDUCTION DOMAIN AND CELL THERAPEUTIC AGENT FOR TREATING DAMAGED TISSUES OR ORGANS INCLUDING THE SAME

摘要

An animal cell is provided to show increased cell adhesiveness to extracellular matrix compared to a conventional animal cell transplanted into damaged tissue organ, thereby showing high survival rate and promoting recovery of the damaged tissue organ. The adhesiveness-enhanced animal cell is characterized in that a fused polypeptide of a tissue transglutaminase(tTG) and a protein transduction domain(PTD) is directly introduced thereinto. The tTG-PTD fused protein is prepared by culturing bacteria transformed by a recombinant vector containing a tTG gene and a PTD gene so as to prepare tTG-PTD fused protein and then recovering the protein therefrom. The cell therapeutic agent for treating damaged tissue or organ comprises the animal cell as an effective ingredient.