Pyrimidine-4,6-dicarboxylic acid diamides for the selectively inhibiting collagenase (MMP 13)

摘要

Pyrimidine-4,6-dicarboxamides of formula (I) wherein the variables are as defined in the specification, that are suitable for the selective inhibition of collagenase (MMP 13) are disclosed. These pyrimidine-4,6-dicarboxamides can thus be used for the treatment of degenerative joint disease, cartilage loss following joint trauma or relatively long joint immobilization following a meniscus or patella injury or a ligament rupture, a disease of the connective tissue, a wound healing disturbance, a chronic disease of the locomotory apparatus or a cancer disease.