<p>Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R<SUB>5</SUB> is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a subslituent R<SUB>18</SUB>, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R<SUB>3</SUB>. Substituent R<SUB>3</SUB> is defined herein.</p>
申请公布号
WO2007021966(A1)
申请公布日期
2007.02.22
申请号
WO2006US31430
申请日期
2006.08.10
申请人
SYNTA PHARMACEUTICALS CORP.;YING, WEIWEN;ZHANG, SHIJIE;DU, ZHENJIAN;FOLEY, KEVIN
发明人
YING, WEIWEN;ZHANG, SHIJIE;DU, ZHENJIAN;FOLEY, KEVIN