发明名称 |
USE OF N-DESMETHYLCLOZAPINE AND RELATED COMPOUNDS AS DOPAMINE STABILIZING AGENTS |
摘要 |
Disclosed herein is the use of N-desmethylclozapine (NDMC) and related compounds to treat a variety of neuropsychiatric diseases including psychosis. It is shown that NDMC and related compounds are agonists or partial agonists at D2 and D3 dopamine receptors and thus may be effective as a dopamine stabilizing agent, allowing it to be used to treat or provide reduced incidence of Extrapyramidal symptoms (EPS) and/or tardive dyskinesias (TD). Also disclosed is administering NDMC and related compounds in combination with other anti-psychotic agents.
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申请公布号 |
WO2006107948(A9) |
申请公布日期 |
2007.02.22 |
申请号 |
WO2006US12463 |
申请日期 |
2006.04.03 |
申请人 |
ACADIA PHARMACEUTICALS INC.;BURSTEIN, ETHAN S. |
发明人 |
BURSTEIN, ETHAN S. |
分类号 |
A61K31/551;A61P25/14 |
主分类号 |
A61K31/551 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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