LIPOSOME COMPOSITION FOR DELIVERY OF THERAPEUTIC AGENTS
摘要
A neutral cationic lipid and liposomes prepared from the neutral cationic lipid are described. Liposomes comprised of the lipid are suitable for delivery of a polyanionic compound, such as a nucleic acid. The delivery can be performed in vivo or ex vivo. The neutral cationic lipid, which is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH, contains a polar head group that imparts solubility of the lipid and permits its packing into a liposomal lipid bilayer.
申请公布号
WO2005070466(A3)
申请公布日期
2007.02.22
申请号
WO2005US01398
申请日期
2005.01.13
申请人
ALZA CORPORATION;ZALIPSKY, SAMUEL;ZHANG, WEIMING;HUANG, SHI, KUN