USE OF PURINERGIC AND PYRIMIDINERGIC RECEPTOR AGONISTS FOR DENDRITIC CELLS BASED IMMUNOTHERAPIES

摘要

The present invention relates to the use of at least one purinergic and pyrimidinergic receptor agonist of formula (I) for the preparation of a medicament for inducing immunotolerance to an antigen, wherein B<SUP>1</SUP> is selected from the group comprising adenine, uracil, thymine, cytosine, guanine, xanthine and hypoxanthine, optionally substituted by thioalkyl, thioaryl, or thioalkylaryl, R<SUP>1</SUP> and R<SUP>2</SUP> represent each independently OH, H, OR<SUP>7</SUP>, OCOR<SUP>7</SUP>, OCOR<SUP>7</SUP>COR<SUP>7</SUP>, wherein R<SUP>7</SUP> represents alkyl or aryl and X is of formula (II), (III) or (IV), wherein R<SUP>10</SUP> represents hydrogen or is of formula (VII), wherein B<SUP>2</SUP> is selected from the group comprising adenine, uracil, thymine, cytosine, guanine, xanthine and hypoxanthine, optionally substituted by thioalkyl, thioaryl, or thioalkylaryl, wherein n is 0, 1, 2, 3 or 4, and wherein R<SUP>4</SUP>, R<SUP>4a</SUP> and R<SUP>4b</SUP> represent each independently O, NH, alkylene, monohaloalkylene or dihaloalkylene and R<SUP>3</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>8</SUP>, R<SUP>9</SUP> represent each independently OH or SH, and wherein R<SUP>11</SUP> and R<SUP>12</SUP> represent each independently OH, H, OR<SUP>7</SUP>, OCOR<SUP>7</SUP>, OCOR<SUP>7</SUP>COR<SUP>7</SUP>, wherein R<SUP>7</SUP> is as defined above.