Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands. The plurality of drugs may be the same or different. Similarly, the vitamin receptor binding ligands may be the same or different. The conjugates also include a linker that is formed from one or more spacer linkers, heteroatom linkers, and releasable linkers.
申请公布号
WO2007022494(A2)
申请公布日期
2007.02.22
申请号
WO2006US32561
申请日期
2006.08.18
申请人
ENDOCYTE, INC.;VLAHOV, IONTCHO, RADOSLAVOV;LEAMON, CHRISTOPHER, PAUL
发明人
VLAHOV, IONTCHO, RADOSLAVOV;LEAMON, CHRISTOPHER, PAUL