| 摘要 |
<p>Compounds according to formula (I) wherein the radicals R<SUP>1</SUP>, R<SUP>2 </SUP>and R<SUP>3</SUP> are as herein defined, and wherein Ar represents an aryl group or heteroaryl group, preferably phenyl, n is 1 or 2, and the radical X represents a group selected from -C(R<SUP>a</SUP>)(R<SUP>b</SUP>)-, -C(R<SUP>a</SUP>)(R<SUP>b</SUP>)-C(R<SUP>a</SUP>)(R<SUP>b</SUP>)-, -C(R<SUP>a</SUP>)=C(R<SUP>a</SUP>)-, OC(R<SUP>a</SUP>)(R<SUP>b</SUP>)- or SC(R<SUP>a</SUP>)(R<SUP>b</SUP>)- . These compounds and their pharmaceutical acceptable salts are used in pharmaceutical compositions as prostaglandine D2 receptor antagonists useful in the treatment of CRTH2 -mediated diseases such as respiratory, inflammatory or allergic conditions among others.</p> |
