发明名称 |
PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY |
摘要 |
Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein. |
申请公布号 |
CA2618377(A1) |
申请公布日期 |
2007.02.22 |
申请号 |
CA20062618377 |
申请日期 |
2006.08.10 |
申请人 |
SYNTA PHARMACEUTICALS CORP. |
发明人 |
YING, WEIWEN;ZHANG, SHIJIE;FOLEY, KEVIN;DU, ZHENJIAN |
分类号 |
C07D231/18;A61K31/415;A61P35/00;C07D231/20;C07D231/38;C07D403/04 |
主分类号 |
C07D231/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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