VARIANTS OF GLYCOGEN SYNTHASE KINASE 3 AND USES THEREOF

摘要

The present invention provides GSK3ß variants, including splice variants expressed in bone or other tissues. These variants have a broad range of functional activity, from inhibiting the Wnt pathway to activating the pathway as dominant-negatives of the full-length GSK3ß. These variants, as well as their modulators, can be used to treat diseases that involve GSK3ß or its associated signaling pathways.