SYSTEMIC AND INTRATHECAL EFFECTS OF A NOVEL SERIES OF PHOSPHOLIPASE A2 INHIBITORS ON HYPERALGESIA AND SPINAL PGE2 RELEASE

摘要

Phospholipase A<SUB>2</SUB> (PLA<SUB>2</SUB>) forins are expressed in spinal cord whose inhibition induces a potent antihyperalgesia. PLA<SUB>2</SUB> inhibitor compounds are provided that include a common motif consisting of a 2-oxoamide with a hydrocarbon tail and a four carbon tether. The compounds block Group IVA calcium dependent PLA<SUB>2</SUB> (cPLA<SUB>2</SUB>) and/or Group VIA calcium independent PLA<SUB>2</SUB> (iPLA<SUB>2</SUB>) and/or Group V secreted PLA<SUB>2</SUB> (sPLA<SUB>2</SUB>).