CANINE TUMOR TREATMENT METHOD, PHARMACEUTICAL FORMULATION APPLIED THERETO, AND METHOD OF CRYOGENICALLY PRESERVING CELLS USED THEREWITH

摘要

A treatment for tumorous canines and a method of preparing, cultivating, a nd cryogenically preserving the pharmaceutical formulation used in the treatmen t. Canine lymphocytes are activated and expanded in the presence of a combination of anti-canine CD3 antibodies and interleukin-2 (IL-2) (preferab ly anti-canine CD3 antibodies and human interleukin-2 (human IL-2)) and administered to tumorous dogs. Following treatment, the canine tumors were observed to be in regression while no serious side effects were noted. Quality-of-life improvements were observed in the form of the animals' abili ty to walk increased distances and improved coat appearance.