摘要 |
The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein G is a direct bond or optionally substituted C<SUB>1-10</SUB>alkanediyl; R<SUP>1 </SUP>is Ar<SUP>1 </SUP>or a monocyclic or bicyclic heterocycle Q is R<SUP>7</SUP>, pyrrolidinyl substituted with R<SUP>7</SUP>, piperidinyl substituted with R<SUP>7 </SUP>or homopiperidinyl substituted with R<SUP>7</SUP>; one of R<SUP>2a </SUP>and R<SUP>3a </SUP>is selected from halo, optionally mono- or polysubstituted C<SUB>1-6</SUB>alkyl, optionally mono- or polysubstituted C<SUB>2-6</SUB>alkenyl, nitro, hydroxy, Ar<SUP>2</SUP>, N(R<SUP>4a</SUP>R<SUP>4b</SUP>) N(R<SUP>4a</SUP>R<SUP>4b</SUP>)sulfonyl, N(R<SUP>4a</SUP>R<SUP>4b</SUP>)carbonyl, C<SUB>1-6</SUB>alkyloxy, Ar<SUP>2</SUP>oxy, Ar<SUP>2</SUP>C<SUB>1-6</SUB>alkyloxy, carboxyl, C<SUB>1-6</SUB>alkyloxycarbonyl, or -C(=Z)Ar<SUP>2</SUP>; and the other one of R<SUP>2a </SUP>and R<SUP>3a </SUP>is hydrogen; in case R<SUP>2a </SUP>is different from hydrogen then R<SUP>2b </SUP>is hydrogen, C<SUB>1-6</SUB>alkyl or halogen and R<SUP>3b </SUP>is hydrogen; in case R<SUP>3a </SUP>is different from hydrogen then R<SUP>3b </SUP>is hydrogen, C<SUB>1-6</SUB>alkyl or halogen and R<SUP>2b </SUP>is hydrogen. It further concerns the preparation thereof and compositions comprising these compounds, as well as the use thereof as a medicine.
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