| 摘要 |
The invention relates to a process for preparation of a compound of formula (I): R<SUP>1</SUP> is selected from C<SUB>1-6</SUB>alkyl, C<SUB>2-6</SUB>alkenyl, and C<SUB>2-6</SUB>alkynyl ; which comprises: (i) reaction with fluoride, suitably [<SUP>18</SUP>F]fluoride, of a corresponding compound of formula (II): wherein R<SUP>2</SUP> is selected from hydrogen, C<SUB>1-10</SUB>alkyl, C<SUB>1-10</SUB>haloalkyl, C<SUB>6-14</SUB>aryl,C<SUB>6-14</SUB>arylalkyl, -(CH<SUB>2</SUB>CH<SUB>2</SUB>O)<SUB>q</SUB>-CH<SUB>3</SUB>wherein q is an integer of from 1 to 10; R<SUP>1</SUP> is as defined for the compound of formula (I); and R<SUP>3</SUP> is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed. |
| 申请人 |
GE HEALTHCARE LIMITED;GE HEALTHCARE AS;STOREY, ANTHONY, EAMON;JONES, CLARE, LOUISE;BOUVET, DENIS, RAYMOND, CHRISTOPHE;LASBISTES, NICOLAS;FAIRWAY, STEVEN, MICHAEL;WILLIAMS, LORENZO;GIBSON, ALEXANDER, MARK;NAIRNE, ROBERT, JAMES;KARIMI, FARHAD;LANGSTROM, BENGT |
发明人 |
STOREY, ANTHONY, EAMON;JONES, CLARE, LOUISE;BOUVET, DENIS, RAYMOND, CHRISTOPHE;LASBISTES, NICOLAS;FAIRWAY, STEVEN, MICHAEL;WILLIAMS, LORENZO;GIBSON, ALEXANDER, MARK;NAIRNE, ROBERT, JAMES;KARIMI, FARHAD;LANGSTROM, BENGT |
