APOE MIMETIC AGENTS

摘要

The invention relates to the use of dimeric oligocationic derivatives for preparing a medicament intended to prevent or treat inflammatory or neurodegenerative disorders, as well as compounds and pharmaceutical compositions for this use. The invention provides low molecular weight apoE mimetic agents suitable for preparing a medicament to treat autoimmune, inflammatory or neurodegenerative disease. The invention provides the use of a compound of general formula (I), or a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended to treat inflammatory disorder: Formula (I) (X)_a - L - (X)_b wherein each X is a (potentially different) chemical moiety bearing a positive charge at physiological pH a and b are, independently, numbers between 3 and 6; and L is a linker. The compounds of general formula (I) may have different X moieties (on both sides of the linker, L), provided only that each bears a positive charge at physiological pH. Such compounds might be of the general structure X1-X2-X3-L-X4-X5-X6, or Xl-Xl-Xl-L- X2-X3-X4, or X1-X1-X1-L-X2-X2-X2, or X1-X1-X1-L-X2-X2-X2.