ANTI-ANGIOGENIC METHODS AND COMPOSITIONS

摘要

Provided herein are zinc finger proteins that bind to particular target sites in the pigment epithelium-derived protein (PEDF) gene and regulate its expression. These zinc finger proteins are used in methods and compositions for regulating angiogenesis. Also disclosed are zinc finger proteins which bind and regulate the expression of the granulocyte-macrophage colony stimulating factor (GM-CSF) gene and their use in methods and compositions that treat tumors.