发明名称 |
VERFAHREN ZUR SYNTHESE VON PEPTIDEN, PEPTIDMIMETIKA UND PROTEINEN |
摘要 |
<p>The method for producing peptides, peptide mimetics and proteins is characterized in that an enzyme is used as a biocatalyst together with a peptide mimetic. The native specificity of the enzyme is modified by chemical or genetic manipulation, the substrate mimetic is a carboxyl component with an ester leaving group whose specificity determinant is adapted to the recognition site of the enzyme. The invention also concerns the trypsin variant D189K,K60E and its use as a C-N ligase in segment condensations.</p> |
申请公布号 |
AT351917(T) |
申请公布日期 |
2007.02.15 |
申请号 |
AT20010976273T |
申请日期 |
2001.10.05 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
BORDUSA, FRANK;JAKUBKE, HANS-DIETER |
分类号 |
C12N15/09;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/76;C12N15/57;C12P21/00;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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