| 摘要 |
The present invention relates to an Exendin 4 polypeptide fragment, which has hypoglycemic activity, and can be used for the treatment of type II diabetes mellitus. The polypeptide sequence described herein is HGEGTX1TSDLSKQX2EEEAVX3LFIEWLKNGX<SUB>4</SUB>PX<SUB>5</SUB>, where X<SUB>1 </SUB>represents Phe or Tyr, X<SUB>2 </SUB>represents Met, Ile or Leu, X<SUB>3 </SUB>represents Lys, X<SUB>4 </SUB>represents Gly or deletion, X<SUB>5 </SUB>represents Arg or deletion. Additionally, the present invention relates to a method for the Exendin 4 polypeptide fragment preparation.
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