ACYLGUANIDINE DERIVATIVE OR SALT THEREOF

摘要

It is intended to provide a compound which can be used for preventing and/or treating a disease associated with 5HT<SUB>2B</SUB> receptor and 5HT<SUB>7</SUB> receptor, particularly for treating irritable bowel syndrome (IBS) and/or preventing migraine. It was found that an acylguanidine derivative characterized by having a tricyclic structure or a pharmaceutically acceptable salt thereof has a strong antagonism to 5HT<SUB>2B</SUB> receptor and 5HT<SUB>7</SUB> receptor. In addition, the compound of the invention having the antagonism to both receptors showed a better pharmacological action compared to the case where an antagonist selective to one of the receptors was solely used. From the above results, the compound of the invention is useful for preventing and/or treating a disease associated with 5HT<SUB>2B</SUB> receptor and 5HT<SUB>7</SUB> receptor, particularly for treating irritable bowel syndrome (IBS) and/or preventing migraine.