发明名称 |
USE OF GSK-3 INHIBITORS FOR PREVENTING AND TREATING PANCREATIC AUTOIMMUNE DISORDERS |
摘要 |
This invention relates to the use of Pax4 stimulating compounds, e.g. Glycogen synthase kinase-3 (GSK-3) inhibitors, particularly in combination with immunomodulating agents, in the prevention, and/or treatment of pancreatic autoimmune disorders, e.g. type I diabetes or LADA. More particularly, this invention relates to the use of compounds selected from paullones, indirubines, substituted ureas, maleimide derivatives and pyrimidine thiones. Further, the present invention relates to a method of identifying and/or characterizing pancreatic beta-cell mitogens by using cells expressing a pancreatic gene or a gene whose function is controlled by a pancreatic gene, particularly the Pax4 gene, and which are transfected with a reporter gene. |
申请公布号 |
WO2006117212(A3) |
申请公布日期 |
2007.02.15 |
申请号 |
WO2006EP04170 |
申请日期 |
2006.05.04 |
申请人 |
DEVELOGEN AKTIENGESELLSCHAFT;MUSSMANN, RAINER;AUSTEN, MATTHIAS;KELTER, ARNDT-RENE;HARDER, FRIEDRICH;AICHER, BABETTE;LOMOW, ALEXANDER |
发明人 |
MUSSMANN, RAINER;AUSTEN, MATTHIAS;KELTER, ARNDT-RENE;HARDER, FRIEDRICH;AICHER, BABETTE;LOMOW, ALEXANDER |
分类号 |
A61P3/10 |
主分类号 |
A61P3/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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