HUMAN GROWTH HORMONE CONJUGATED WITH BIOCOMPATIBLE POLYMER

摘要

The present invention relates to conjugates of biocompatible polymers and hG H, particularly PEG-hGH, where the activated biocompatible polymer is conjugate d to a carboxyl group of hGH at a molar ratio of 2:1 or less, preferably 1:1, methods of preparation, and related pharmaceutical compositions. The PEG-hGH conjugates have up to 20% of the activity of the native hGH while the in viv o half life is increased 10 fold. The PEG-hGH conjugates may be used therapeutically to treat growth retardation or growth failure, especially short stature in children, and conditions related to aging.