TAXOID DERIVATIVE BOUND TO TUMOR-SPECIFIC ANTIBODY AND METHOD FOR PRODUCING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a taxoid derivative by improving solubility in water, specifically acting on tumors and thereby having reduced adverse effects and to provide a method for producing the same. SOLUTION: An anti-cancer agent is obtained by binding an antibody specifically reactive with cancer cells to a taxoid derivative. The method for producing the anti-cancer agent comprises reacting the taxoid derivative with periodic acid or a periodate and further reacting the resultant reaction product with the antibody specifically reactive with the cancer cells in the presence of a reducing agent. COPYRIGHT: (C)2007,JPO&INPIT