CAMPTOTHECIN DERIVATIVES CONJUGATED IN POSITION 20 WITH INTEGRIN ANTAGONISTS

摘要

Compounds or formula (I) are described, in which R and R₁ groups are as defined here below and include the condensation of the camptothecin molecule in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors a_vß₃ and a_vß₅ and with selective cytotoxic activity on human tumor cell lines at micromolar concentrations.