发明名称 |
Using Inhibitors of Histone Deacetylases for the Suppression Therapy of Inherited Disease Predisposing Conditions |
摘要 |
Compounds can be used to act as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as but not limited to cancer, inflammatory or metabolic diseases. Such conditions are linked to genetically inherited mutations of crucial genes which predispose a person with this condition to develop the disease phenotype. Thus, such compounds can be used for a suppressive therapeutic approach-the SUPPRESSION THERAPY-in order to inhibit or delay the onset or progression of the genetically predisposed disorder. Furthermore, a clinically used medicament can be manufactured for the SUPPRESSION THERAPY of such inherited predisposing conditions.
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申请公布号 |
US2007037738(A1) |
申请公布日期 |
2007.02.15 |
申请号 |
US20050275263 |
申请日期 |
2005.12.21 |
申请人 |
HENTSCH BERND;MAURER ALEXANDER B;HOVELMANN SASCHA;RAAB MONIKA;MARTIN ELKE |
发明人 |
HENTSCH BERND;MAURER ALEXANDER B.;HOVELMANN SASCHA;RAAB MONIKA;MARTIN ELKE |
分类号 |
A61K38/12;A61K31/19;A61K31/20;A61K31/4436;A61K31/505;A61P35/00 |
主分类号 |
A61K38/12 |
代理机构 |
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