Benzylamine analogues

摘要

A compound of the formula (1): wherein R¹ is a C₁-C₆ alkyl, an amino, a (C₁-C₆ alkyl)amino, a di(C₁-C₆ alkyl)amino or a nitrogen-containing saturated heterocyclic; R² and R³ are the same or different and are a hydrogen or a C₁-C₆ alkyl; Arom is an unsubstituted or substituted aryl or an unsubstituted or substituted heteroaryl; wherein the substituted aryl is substituted at 1 to 5 positions and the substituted heteroaryl is substituted at 1 to 3 positions; wherein the heteroaryl is furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; and wherein the substituents of the substituted aryl and of the substituted heteroaryl are independently halogen, C₁-C₆ alkyl, halogeno C₁-C₆ alkyl, C₁-C₆ alkoxy, C₁-C₆ alkylthio, C₁-C₃ alkylenedioxy, C₁-C₇ alkanoyl, C₂-C₇ alkyloxycarbonyl, amino, C₁-C₇ alkanoylamino, hydroxyl, mercapto, cyano, nitro or carboxyl; A is an ethylene or propylene; R^a is a hydrogen, a C₁-C₆ alkyl or a C₂-C₆ alkenyl; E is a single bond, an oxygen, a sulfur or -NR⁴-, wherein R⁴ is a hydrogen or a C₁-C₇ alkanoyl; X¹ and X² are the same or different and are an oxygen or a sulfur, or a pharmacologically acceptable salt or ester thereof.