GENE EXPRESSION TECHNIQUE

摘要

The present invention provides a host cell suitable for enhanced production of a protein product of choice characterised in that the host cell is genetically modified to cause over-expression of two or more helper proteins selected from a DnaJ-like protein (such as JEMl), an Hsp70 family protein (such as LHSl) and SILl wherein at least one of the over-expressed two or more helper proteins is selected from JEMl, LHSl and SILl, and wherein the DnaJ-lilce protein is not SCJl.