PYRIDONE COMPOUND

摘要

An active ingredient is a compound represented by the general formula [I]: [I] [wherein R<SUB>1</SUB> and R<SUB>2</SUB> represent a lower alkyl group, a C<SUB>3-8</SUB> cycloalkyl group or the like, X<SUB>1</SUB> and X<SUB>2</SUB> represent methine, an Ar-Y<SUB>1</SUB>-Y<SUB>2</SUB>-Y<SUB>3</SUB>-substituted methine or the like, however, either of them is an Ar-Y<SUB>1</SUB>-Y<SUB>2</SUB>-Y<SUB>3</SUB>-substituted methine, X<SUB>3</SUB> to X<SUB>8</SUB> represent methine, -N- or the like, Y<SUB>1</SUB> and Y<SUB>3</SUB> represent a single bond, -O- or the like, Y<SUB>2</SUB> represents a single bond, a lower alkylene group or the like, W represents -(O)-(CH<SUB>2</SUB>)<SUB>n</SUB>-(O)- or the like, n represents an integer of 1 to 4, L and Z<SUB>2</SUB> represent a single bond or a methylene group, Z<SUB>1</SUB> represents a single bond, a C<SUB>1-4</SUB> alkylene group or the like, and Ar represents an aromatic carbocyclic group or the like]. The compound acts as a melanin-concentrating hormone receptor antagonist and is useful as a therapeutic agent for obesity or the like.