TRANSGENIC ALZHEIMER'S MOUSE MODEL VECTORS AND USES THEREOF

摘要

The present invention provides for a recombinant nucleic acid molecule comprising a humanized mouse /3-amyloid precursor protein ("APP") gene comprising K670N, M671L and V717F mutations and uses thereof. The present invention further provides for a recombinant nucleic acid molecule comprising a region of a calcium-calmodurin dependent kinase Ila ("CaMKIIa") promoter operatively linked to a /3-amyloid precursor protein ("APP") gene comprising at least one mutation and uses thereof.