摘要 |
The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y is -NR<SUP>a</SUP>R<SUP>b</SUP>, -NR<SUP>c</SUP>C=ONR<SUP>a</SUP>R<SUP>b'</SUP> -NR<SUP>c</SUP>C=SNR<SUP>a</SUP>R<SUP>b</SUP>, -NR<SUP>c</SUP>C=NR<SUP>d</SUP>N<SUP>a</SUP>R<SUP>b</SUP>, heterocycle, - C=ONR<SUP>a</SUP>R<SUP>b</SUP>, heterocycle, or aryl; n is O to 8; m is 0, or 1 ; r is 0 to 3; t is O to 3; X is O or N; Z is CH<SUB>2</SUB>, C=O, C=S or a single bond; Z<SUP>1</SUP> is CO-R<SUP>2</SUP>, CS-R<SUP>2</SUP>, (CH<SUB>2</SUB>)<SUB>t</SUB>-R<SUP>2</SUP> or the side-chain of a naturally occuring amino acid; , Z<SUP>2</SUP> is CO-R<SUP>2</SUP> , CS-R<SUP>2</SUP> or (CH<SUB>2</SUB>)<SUB>t</SUB>-R<SUP>3</SUP> or the side-chain of a naturally occuring amino acid; Z<SUP>3</SUP> is CO-R<SUP>2</SUP>, CS-R<SUP>2</SUP> or (CH<SUB>2</SUB>)<SUB>t</SUB>-R<SUP>4</SUP> or the side-chain of a naturally occuring amino acid; Z<SUP>4 </SUP>is H, alkyl, alkoxy, or cycloalkyl; R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, and R<SUP>4</SUP> are independently from each other H, OH, SH, NH<SUB>2</SUB>, CN, NO<SUB>2</SUB>, alkyl, cycloalkyl, heterocycloalkyl, haloalkyl, alkylthio, haloalkyloxy, hydroxyalkyl, hydroxyalkylarnino, alkylamino, alkylaryl, alkylsulfinyl, alkylsulfonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxyalkyl, alkoxy, aryloxy, heteroaryl, aryl, or halogen. |