| 发明名称 |
CAMPTOTHECINS CONJUGATED IN POSITION 7 TO CYCLIC PEPTIDES AS CYTOSTATIC AGENTS. |
| 摘要 |
<p>Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors alphavbeta3 and alphavbeta5 and with selective cytotoxic activity on human tumor cell lines at micromolar concentrations.</p> |
| 申请公布号 |
MXPA06012884(A) |
申请公布日期 |
2007.02.15 |
| 申请号 |
MX2006PA12884 |
申请日期 |
2005.05.04 |
| 申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. |
发明人 |
MARIA ORNELLA TINTI;SERGIO PENCO;CLAUDIO PISANO;LUCIO MERLINI;SABRINA DALLAVALLE;GIUSEPPE GIANNINI;LOREDANA VESCI;DOMENICO ALLOATTI;FRANCO ZUNINO;ALMA DAL POZZO;NI MINGHONG |
| 分类号 |
C07K7/64;A61K38/00;A61K38/08;C07K7/52 |
主分类号 |
C07K7/64 |
| 代理机构 |
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